No one diet can treat Parkinson’s disease, but medication might require mealtime considerations and dietary changes may help ease certain symptoms. Your physician or a dietitian can design a healthy, balanced diet to fit your needs and improve well-being. There is no one recommended way to eat with Parkinson’s disease, but a balanced diet full of fruits and vegetables promotes health and well-being for everyone. One part of a healthy diet is eating foods with antioxidants. These “good for you” molecules help protect cells from stresses such as air pollution, cigarette smoke and even the process of converting food to energy. Antioxidants are found in fruits, vegetables, grains, nuts, dark chocolate and some beverages, such as red wine, coffee and tea. Talk to your doctor or a dietitian to craft a diet that helps you manage your Parkinson’s symptoms and feel energized and healthy. The medication levodopa Sinemet is a protein building block, so it competes for absorption with other proteins.
Department of Agriculture MyPlate program. Optimal protein intake in the elderly. This finding parminsons although PRD might be able to enhance the response to levodopa in PD patients, its ability to initiate a response to the drug was limited Riley and Lang,
Levodopa is considered to be the most effective symptomatic drug for Parkinson’s disease PD. As the disease progresses, however, the patients are likely to experience a reduced response to levodopa and develop motor fluctuations i. Protein-rich diets and elevated plasma concentrations of large neutral amino acids have been proved to impair the therapeutic effect of levodopa by reducing its absorption and influx into the brain. On the other hand, the protein-restricted diets including low-protein diet LPD, protein-redistribution diet PRD and PRD with use of low-protein products can all improve the efficacy of levodopa in patients with motor fluctuations. However, it should be noted that protein-restricted diets may also contribute to several side effects, including dyskinesia, weight loss, and malnutrition e. Together, protein-restricted diets are an effective approach to improve motor fluctuations in PD patients, while long-term adherence to these diets requires monitoring for side effects. Motor symptoms of the disease include bradykinesia, muscular rigidity, rest tremor, as well as postural, and gait impairment Kalia and Lang, However, with prolonged treatment, the patients are likely to show a reduced response to levodopa, and develop motor complications including motor fluctuations and dyskinesia Jankovic and Stacy, ; Kalia and Lang, Fluctuating motor performance is the major source of disability in PD patients, and significantly impairs their quality of life QOL; Chapuis et al.
Furthermore, the effect of dietary LNAAs on levodopa efficacy has been furtherly confirmed by another two studies. Another option is to save higher amounts of protein for the end of the day, when controlling symptoms may not be as critical. However, the digestion of dietary protein results in certain amino acids, large neutral amino acids-LNAAs which compete with levodopa for transport into the brain. The influence of protein containing meals on the pharmacokinetics of levodopa in healthy volunteers. Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography. Moreover, Mena et al. Motor fluctuations and dyskinesias in Parkinson’s disease: clinical manifestations. The recent study performed by Barichella et al. Additional research, especially cohort studies, will be required in order to explore the cinical benefits of a prolonged PRD. Drink alcoholic beverages in moderation, as they have empty calories and few or no nutrients. This condition results in food remaining in the stomach for an abnormally long period of time.