Metrics details. Ketogenic diets KDs include a high amount of fat, low carbohydrate and medium-chain triglyceride MCT intake. KDs lead to the production of ketone bodies to fuel the brain, in the absence of glucose. These nutritional interventions are validated treatments of pharmacoresistant epilepsy, consequently leading to a better intellectual development in epileptic children. The main objective of this review was to critically examine the evidence regarding KD or MCT intake effects both in AD and ageing animal models and in humans. Overall, 11 animal and 11 human studies were included in the present review. In preclinical studies, this review revealed an improvement of cognition and motor function in AD mouse model and ageing animals. However, the KD and ketone supplementation were also associated with significant weight loss. In human studies, most of the published articles showed a significant improvement of cognitive outcomes global cognition, memory and executive functions with ketone supplementation or KD, regardless of the severity of cognitive impairments previously detected.
At the same time, those studies did not assess the effects of the KD, a diet supplying big fat volumes. It is associated with improved cognitive performance in elderly adults with AD. Eleven of the participants had MCI and six had no cognitive issues. Acta Physiol. Pawlosky R. Prins M. Food Sci.
My elderly parents — fiercely independent, living on their own, and aging relatively well — are highly motivated to keep their brains functioning at an optimal level. A significant loss of cognitive skills in either one of them would seriously threaten their cherished freedoms and greatly reduce their quality of life. A few of us remarked on having improved mental clarity — a benefit some people have reported from the ketogenic lifestyle. My mom was having some memory problems that frustrated and scared her, such as having difficulty writing down items on a shopping list. She knew what she needed, but the names or spellings sometimes would not come. She had voluntarily given up driving last year as she knew that at random times, especially under stress, she would have moments of confusion.