It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia ALL have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. Some DIO mice were switched to the low-fat control diet. Survival from ALL was assessed without or with chemotherapy treatment starting at the time of the diet switch. Similar experiments were done with human ALL xenografts. Interestingly, while serum restriction enhanced ALL sensitivity to dexamethasone and l -asparaginase, dietary switch did not improve survival of DIO mice treated with either drug in monotherapy. Thus, it appears that dietary intervention has a unique effect to improve ALL cell sensitivity to vincristine in vivo. We report herein that a dietary intervention can improve ALL outcome in a preclinical model.
Your website access code is located in the upper right corner of the Table of Contents page of your digital edition. Several of these target P13K, an enzyme involved in cellular growth that is known to contribute to causing cancers. The problem is that the drugs also cause a spike in insulin, which helps tumors grow. The spike could compromise the effectiveness of the cancer therapies. Researchers found that the diet improved the effectiveness of anti-cancer drugs by reducing blood insulin. Cantley, the lead author of the paper. Since the s, so-called keto diets have been used in medicine to reduce epileptic seizures. More recently, the diets have supplemented standard treatments for Type 2 diabetes and cancer. The body switches from glucose to fatty acids as a fuel, which burns fat, enabling people to lose weight. The switch also generates the production of ketones, which are energy molecules that are made in the liver. But keto diets have not always been effective in supplementing standard treatments for some types of cancer. In mice studies involving acute myeloid leukemia, a cancer of the blood and bone marrow, for instance, the dietary change actually accelerated the disease, the Nature paper says.
Assured ketogenic diet and leukemia are not
Overexpression of glucose transporters 1 and 3 Glut-1, Glut-3 also occurs in many cancers and corresponds to the degree of glucose uptake in aggressive tumors, as seen on positron emission tomography PET. However, in the mid-to-late s, with the establishment of the Charlie Foundation, the diet slowly started regaining recognition. Donate Now. Nutr Metab Lond ; 7 Weight control interventions improve therapeutic efficacy of dacarbazine in melanoma by reversing obesity-induced drug resistance. Survival from ALL was assessed without or with chemotherapy treatment starting at the time of the diet switch. Cantley, the lead author of the paper. Competing interests The authors declare that they have no competing interests. Jocelyn Tan-Shalaby, MD. The result is that the cancer cells become heavily dependent on ATP coming from the less efficient process of glycolysis Figure 1. Gadi, a clinical researcher and breast cancer oncologist with Fred Hutch and its clinical-care partner, Seattle Cancer Care Alliance.